Gene information
Official symbol HSPB1
Official full name heat shock protein family B (small) member 1
Gene type protein-coding gene
Chromosome7q11.23
Alias symbolHSP27; HSP28; Hs.76067; Hsp25; CMT2F
Gene familySmall heat shock proteins
Resources
Entrez Gene 3315
HGNC HGNC:5246
Ensembl ENSG00000106211
Vega OTTHUMG00000023228
UCSC uc003uew.4
GO terms: 98 records
GO Description Category LogP Number of genes Detail
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001894 tissue homeostasis GO Biological Processes -10.3152206 20 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0006457 protein folding GO Biological Processes -2.73896005 9 More
GO:0006469 negative regulation of protein kinase activity GO Biological Processes -12.6852914 37 More
GO:0006986 response to unfolded protein GO Biological Processes -2.24519355 6 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008134 transcription factor binding GO Molecular Functions -5.50998540 50 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009408 response to heat GO Biological Processes -9.27499209 13 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0010506 regulation of autophagy GO Biological Processes -5.54010569 34 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0019207 kinase regulator activity GO Molecular Functions -2.87704457 10 More
GO:0019210 kinase inhibitor activity GO Molecular Functions -2.42307363 9 More
GO:0019887 protein kinase regulator activity GO Molecular Functions -2.69690139 9 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0030016 myofibril GO Cellular Components -10.5185909 20 More
GO:0030017 sarcomere GO Cellular Components -8.52596130 17 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030168 platelet activation GO Biological Processes -17.9354931 20 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032731 positive regulation of interleukin-1 beta production GO Biological Processes -11.8061175 13 More
GO:0032732 positive regulation of interleukin-1 production GO Biological Processes -14.7376831 16 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0033673 negative regulation of kinase activity GO Biological Processes -12.5521161 39 More
GO:0034109 homotypic cell-cell adhesion GO Biological Processes -7.07578331 9 More
GO:0035924 cellular response to vascular endothelial growth factor stimulus GO Biological Processes -8.07167727 14 More
GO:0035966 response to topologically incorrect protein GO Biological Processes -3.19318664 8 More
GO:0038084 vascular endothelial growth factor signaling pathway GO Biological Processes -6.53278734 9 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043292 contractile fiber GO Cellular Components -11.9705216 22 More
GO:0043536 positive regulation of blood vessel endothelial cell migration GO Biological Processes -25.0316183 33 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0048010 vascular endothelial growth factor receptor signaling pathway GO Biological Processes -5.65848894 6 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0060249 anatomical structure homeostasis GO Biological Processes -12.3640817 24 More
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding GO Molecular Functions -8.00802452 40 More
GO:0070527 platelet aggregation GO Biological Processes -8.40921139 9 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:0098930 axonal transport GO Biological Processes -1.35686085 3 More
GO:0140297 DNA-binding transcription factor binding GO Molecular Functions -6.94737226 46 More
GO:1900407 regulation of cellular response to oxidative stress GO Biological Processes -21.4526227 33 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO Biological Processes -8.56934819 8 More
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO Biological Processes -8.38095721 7 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1902882 regulation of response to oxidative stress GO Biological Processes -20.0046302 33 More
GO:1903201 regulation of oxidative stress-induced cell death GO Biological Processes -18.4601079 28 More
GO:1903202 negative regulation of oxidative stress-induced cell death GO Biological Processes -17.0330784 23 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1904115 axon cytoplasm GO Cellular Components -1.32158811 3 More
GO:1905368 peptidase complex GO Cellular Components -4.61293625 9 More
GO:1905369 endopeptidase complex GO Cellular Components -3.16416938 6 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2001026 regulation of endothelial cell chemotaxis GO Biological Processes -8.98205881 11 More
GO:2001028 positive regulation of endothelial cell chemotaxis GO Biological Processes -5.99718380 5 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001242 regulation of intrinsic apoptotic signaling pathway GO Biological Processes -16.0885267 23 More
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway GO Biological Processes -12.4318822 16 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
Drug-Gene interaction
view
Related drugs: 31 records
Drug name Interaction type Source PMID View
albendazole DTC view
alpha-terthienyl DTC view
apatorsen inhibitor TdgClinicalTrialCancerCommonsTTD view
benzenethiol DTC view
benzo(k)fluoranthene DTC view
bufotenine DTC view
chembl1935538 DTC 22435708 view
chembl2094499 DTC view
chembl2332783 DTC view
chembl333177 DTC view
cloxyquin DTC view
cridanimod DTC view
cyclofenil DTC view
cyromazine DTC view
dicarbonodithioimidic diamide DTC view
e-guggulsterone DTC view
feprazone DTC view
hydrastinine hydrochloride DTC view
hymecromone DTC view
mometasone furoate DTC view
nocodazole DTC 22435708 view
omeprazole DTC view
phenanthroline DTC view
quercetin DTC 19296652 view
rhamnetin DTC 19296652 view
rofecoxib NCI 16041694 view
teroxirone DTC view
triamterene DTC view
urea NCI 9094264 view
vasopressin NCI 9925748 view
zearalenone DTC view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
heat shock protein beta-1 proteomics good predictor high thrombus burden[prognosis (bad)] acute ST elevation myocardial infarction Tian M et al. Oncotarget. 2017
heat shock protein beta-1 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Kraemer BF et al. Int J Mol Sci. 2019
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